On page 6 of Ghostbusters Volume 2 Issue #1, Slime-C makes a cameo in the refrigerator.

On page 12 of Ghostbusters Issue #14, Slime-C makes a cameo as one of the beverages for sale.

On page 10 of Ghostbusters Issue #3, Slime-C, a variation on the Ecto Cooler box appears on an advertisement.

On December 17, 2021, Hi-C announced that the Ecto Cooler promotion had ended. On November 15, 2021, Ecto Cooler 12 oz bottles were handed out during the New York premiere of Ghostbusters: Afterlife. On November 14, 2021, Hi-C's social media asked fans to share their love and posted an old 1989 clip ending with a new promo of Mini-Pufts with a 12 oz bottle but clarified it won't be for sale. On November 11, 2021, official accounts on both Twitter and Instagram under the handle of were created. A rotating advertisement depicted the Mini-Pufts and the original Ecto Cooler. On October 31, 2021, it was reported Ecto Cooler was being used at a Sony-Pictures/Firefly promotional event for Ghostbusters: Afterlife in New York and Los Angeles. On November 2, 2016, it was announced that Ecto Cooler was going to be discontinued by December 2016. On May 30, 2016, it was reported ads for Ecto Cooler were seen in a movie theater. It was sold exclusively in the United States of America. Fans were instructed follow on Twitter and Ecto Cooler on Facebook. Fans can enter for a chance to win it before it is available for purchase. There was a contest that held up until May 30. The cans are specially printed using thermal ink that turns an eerie shade of slime green when the product inside is cold. It will be sold in packs of 6-ounce juice boxes or 11.5-ounce aluminum cans. On April 25, 2016, it was announced Ecto Cooler would be available for a limited time beginning on May 30. The new can did not feature the iconic Slimer, but notes the 2016 film and has a green slime motif. Then appearing on eBay on February 18, 2016, was a prototype can. On September 15, 2015, Coca-Cola filed to renew the Ecto Cooler trademark.

The next year, Crazy Citrus Cooler was discontinued. In 2006, Shoutin' Orange Tangergreen was renamed Crazy Citrus Cooler. While it didn't taste any different, it did change to a yellowish-green. During the Shoutin' Orange Tangergreen era, the formula was changed along with the rest of the line of Hi-C drinks to a 'Won't Stain' formula. The product was still noted as ecto cool on many store receipts. Slimer was replaced on the packaging by a similar-looking blob of lips. Slimer left the box design around 1997, but Minute Maid did not discontinue the product until 2001, at which point it was renamed Shoutin' Orange Tangergreen. The drink did surprisingly well in some markets and continued way beyond The Real Ghostbusters run. It is notable that Ecto Cooler was made in light of Ghostbusters II, which was in theaters when released. It was a repurpose of Hi-C's “Citrus Cooler”, which had been around since the 60's.

In 1989, Hi-C released a new flavour featuring a image of Slimer from The Real Ghostbusters on the box, naming the flavour 'Ecto Cooler'.

Ecto cooler leafly